Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975292 | 0.89 | PAK4 (0.41) | ZAP70EGFRTTKJAK2JAK1 | |
| SCHEMBL3971227 | 0.83 | TTK (0.44) | EGFRTTKMAP3K7LRRK2AXL | |
| SCHEMBL3970291 | 0.83 | TTK (0.63) | EGFRTTKMAP3K7JAK2JAK1 | |
| SCHEMBL13883571 | 0.80 | SRC (0.46) | EGFRAXLJAK2JAK1JAK3 | |
| SCHEMBL4082415 | 0.78 | TTK (0.46) | EGFRTTKLRRK2CDK2AURKA | |
| SCHEMBL3966581 | 0.78 | JAK2 (0.51) | EGFRTTKLRRK2JAK2JAK1 | |
| SCHEMBL4078306 | 0.77 | TTK (0.62) | TTKLRRK2CDK2AURKAJAK2 | |
| SCHEMBL3970170 | 0.77 | TTK (0.51) | EGFRTTKCDK2CCNA2JAK2 | |
| SCHEMBL3969173 | 0.76 | TTK (0.40) | TTKLRRK2AXLAURKAJAK2 | |
| SCHEMBL3967981 | 0.76 | PTK2 (0.42) | EGFRJAK2JAK1JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |