Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 10/20 | 0.44 |
| ▸ | YES1 | P07947 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883571 | 0.94 | SRC (0.46) | SRCYES1AXLPDGFRBEGFR | |
| SCHEMBL4082415 | 0.92 | TTK (0.46) | TTKSRCLRRK2PRKCQPRKCD | |
| SCHEMBL3970118 | 0.85 | SRC (0.46) | SRCYES1PRKCQPDGFRB | |
| SCHEMBL3967981 | 0.83 | PTK2 (0.42) | SRCEGFRKDRLCKMAPK14 | |
| SCHEMBL3970291 | 0.83 | TTK (0.63) | TTKEGFRMAP3K7 | |
| SCHEMBL3969752 | 0.83 | ZAP70 (0.48) | TTKLRRK2AXLEGFRMAP3K7 | |
| SCHEMBL3969959 | 0.81 | JAK3 (0.38) | YES1PDGFRBEPHB4 | |
| SCHEMBL13883580 | 0.81 | AXL (0.46) | SRCYES1AXLPDGFRBEGFR | |
| SCHEMBL3969268 | 0.81 | HRH3 (0.46) | SRCAXL | |
| SCHEMBL3971647 | 0.80 | PDPK1 (0.47) | TTKPRKCQPRKCDAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |