Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966066 | 0.87 | AXL (0.41) | JAK2JAK1TYK2JAK3HRH3 | |
| SCHEMBL13881481 | 0.86 | HPGD (0.54) | HPGDJAK2JAK1TYK2JAK3 | |
| SCHEMBL3969743 | 0.85 | AXL (0.42) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3971087 | 0.82 | AXL (0.41) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3967433 | 0.82 | AXL (0.44) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3971221 | 0.81 | JAK2 (0.41) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3965200 | 0.80 | AXL (0.41) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3967985 | 0.80 | AXL (0.39) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL3967352 | 0.80 | CHEK1 (0.39) | JAK2JAK1TYK2JAK3HRH3 | |
| SCHEMBL3965488 | 0.80 | CHRNA1 (0.41) | JAK2JAK1TYK2JAK3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |