Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 5/20 | 0.42 |
| ▸ | MERTK | Q12866 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975392 | 0.93 | PDPK1 (0.43) | PDPK1KDRPLK1JAK2JAK3 | |
| SCHEMBL3974734 | 0.91 | KDR (0.46) | KDRJAK2JAK3TTKCDK2 | |
| SCHEMBL3970170 | 0.85 | TTK (0.51) | JAK2JAK3BRD4TTKCDK2 | |
| SCHEMBL3969173 | 0.83 | TTK (0.40) | PDPK1KDRAXLMERTKJAK2 | |
| SCHEMBL3967492 | 0.82 | MAPK1 (0.41) | PDPK1KDRAXLMERTKJAK2 | |
| SCHEMBL3970201 | 0.82 | MAPK1 (0.41) | PDPK1KDRAXLMERTKJAK2 | |
| SCHEMBL3970782 | 0.81 | PLK4 (0.41) | KDRAXLMERTKJAK2JAK3 | |
| SCHEMBL13883513 | 0.81 | PDE5A (0.49) | JAK2BRD4TTKCDK2AURKA | |
| SCHEMBL13883562 | 0.81 | IRAK4 (0.49) | PDPK1CDK2CCNA2 | |
| SCHEMBL4073485 | 0.81 | TTK (0.47) | KDRAXLJAK2JAK3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |