Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.47 |
| ▸ | CDK2 | P24941 | 11/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.47 |
| ▸ | CDK9 | P50750 | 10/20 | 0.47 |
| ▸ | CDK1 | P06493 | 8/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.47 |
| ▸ | CDK7 | P50613 | 8/20 | 0.47 |
| ▸ | CCNH | P51946 | 8/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970170 | 0.91 | TTK (0.51) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL4078306 | 0.80 | TTK (0.62) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL3970291 | 0.80 | TTK (0.63) | PTK2TTK | |
| SCHEMBL3970782 | 0.80 | PLK4 (0.41) | CDK2CCNA1PTK2TTKPAK4 | |
| SCHEMBL3975392 | 0.79 | PDPK1 (0.43) | CDK1PDPK1PAK4 | |
| SCHEMBL3971647 | 0.78 | PDPK1 (0.47) | CCNA2CDK2CCNA1PTK2TTK | |
| SCHEMBL3974734 | 0.77 | KDR (0.46) | CCNA2CDK2CDK1CCNA1PTK2 | |
| SCHEMBL13883513 | 0.77 | PDE5A (0.49) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL13883562 | 0.77 | IRAK4 (0.49) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3970118 | 0.76 | SRC (0.46) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |