SCHEMBL397020

SCHEMBL397020

Clc1cc(Cl)c2ccccc2n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.54
MAOB P27338 1/20 0.54
KDM4E B2RXH2 3/20 0.50
HTT P42858 2/20 0.49
USP2 O75604 1/20 0.49
IGF1R P08069 2/20 0.47
KMT2A Q03164 4/20 0.45
MAPT P10636 5/20 0.44
ALDH1A1 P00352 4/20 0.43
TDP1 Q9NUW8 3/20 0.43
GAA P10253 3/20 0.43
MEN1 O00255 2/20 0.43
GLA P06280 2/20 0.43
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
POLB P06746 1/20 0.43
CHRM2 P08172 1/20 0.43
ADRA2A P08913 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29420516 1.00 MAOA (0.54) MAOAMAOBKDM4EHTTUSP2
SCHEMBL6089983 0.79 KMT2A (0.48) MAOAMAOBKDM4EHTTUSP2
SCHEMBL29850612 0.78 NCF1 (0.60) MAOAMAOBKDM4EHTTUSP2
SCHEMBL11343689 0.78 KMT2A (0.53) MAOAMAOBKDM4EHTTUSP2
SCHEMBL29091586 0.78 MAOA (0.50) MAOAMAOBKDM4EHTTUSP2
SCHEMBL6457778 0.78 KDM4E (0.51) MAOAMAOBKDM4EHTTUSP2
SCHEMBL1845376 0.78 NCF1 (0.60) MAOAMAOBKDM4EHTTUSP2
SCHEMBL3968023 0.78 MAOA (0.50) MAOAMAOBKDM4EHTTUSP2
SCHEMBL832589 0.78 CYP1A2 (0.64) MAOAMAOBKDM4EHTTUSP2
SCHEMBL17508369 0.78 MAOA (0.56) MAOAMAOBKDM4EHTTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 586 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113121435-B Synthetic method of 2, 4-dichloroquinoline compound 辽宁大学 2022-08-30 CN claimed
CN-113121435-A Synthetic method of 2, 4-dichloroquinoline compound 辽宁大学 2021-07-16 CN claimed
CN-107163251-B High temperature resistant poly arylidene thio-ester analog copolymer and preparation method thereof 四川大学 2019-08-09 CN claimed
CN-107163251-A High temperature resistant poly arylidene thio-ester analog copolymer and preparation method thereof 四川大学 2017-09-15 CN claimed
WO-2026107328-A1 AGONISTS OF PARATHYROID HORMONE 1 AND INCRETIN RECEPTORS SEPTERNA, INC. (US) 2026-05-21 WO disclosed
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 EP disclosed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 US disclosed
US-12486285-B2 BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2025-12-02 US disclosed
EP-4010330-B1 QUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS HIRUNDO BIOSCIENCES (BE) 2025-10-01 EP disclosed
US-12404249-B2 Heterocyclic derivatives and use thereof C&C RESEARCH LABORATORIES (KR) 2025-09-02 US disclosed
EP-4592286-A1 MACROCYCLIC NITROGEN-CONTAINING CROWN ETHER COMPOUND AND USE THEREOF AS PROTEIN KINASE INHIBITOR Artivila Biopharma (CN) 2025-07-30 EP disclosed
EP-3802495-B1 4-(2-((2-CHLOROQUINOLIN-4-YL)AMINO)ETHYL)BENZENESULFONAMIDE DERIVATIVES AS STAT3 INHIBITORS FOR THE TREATMENT OF CANCER C&C RES LAB (KR) 2025-07-02 EP disclosed
US-5114940-A Insecticides or anthelmintics from fused ring heterocycles containing amides or thioamides ROUSSEL-UCLAF (FR) 1992-05-19 US disclosed
EP-0326331-A2 Substituted quinolines and cinnolines DowElanco (US) 1989-08-02 EP disclosed
EP-0172427-B1 PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER Shin-Etsu Chemical Co., Ltd. (JP) 1989-07-05 EP disclosed
EP-0317188-A2 Heteroaromatic enamide derivatives and their use as pesticides ROUSSEL UCLAF (FR) 1989-05-24 EP disclosed
US-4758639-A Process for production of vinyl polymer SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-19 US disclosed
US-4757124-A Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-12 US disclosed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP disclosed
US-3953457-A S-TRIAZOLO(4,3-A)QUINOLINE COMPOUNDS ELI LILLY AND COMPANY (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12486285-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 MAOA 4129/4885MAOB 2664/4885KDM4E 481/4885
US-12404249-B2 Heterocyclic derivatives and use thereof STAT3, JAK2, IRF3 MAOA 4183/4885MAOB 3955/4885KDM4E 3797/4885
US-20260042776-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL9 MAOA 4205/4885MAOB 2655/4885KDM4E 190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.