Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883520 | 0.92 | LRRK2 (0.41) | LRRK2CHRNA7PDPK1AXLMERTK | |
| SCHEMBL3969173 | 0.86 | TTK (0.40) | LRRK2PDPK1AXLMERTKMET | |
| SCHEMBL3967492 | 0.86 | MAPK1 (0.41) | LRRK2PDPK1AXLMERTKMET | |
| SCHEMBL3970201 | 0.86 | MAPK1 (0.41) | LRRK2PDPK1AXLMERTKMET | |
| SCHEMBL3975882 | 0.86 | AXL (0.35) | LRRK2AXLMERTKMETJAK3 | |
| SCHEMBL3970782 | 0.85 | PLK4 (0.41) | LRRK2AXLMERTKMETJAK3 | |
| SCHEMBL4073485 | 0.84 | TTK (0.47) | LRRK2AXLJAK3KDRCHEK1 | |
| SCHEMBL3971647 | 0.78 | PDPK1 (0.47) | PDPK1AXLMERTKMETJAK3 | |
| SCHEMBL3975392 | 0.77 | PDPK1 (0.43) | PDPK1ALDH1A1JAK3KDRJAK2 | |
| SCHEMBL13883586 | 0.76 | CYP11B1 (0.42) | JAK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |