Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970930 | 1.00 | REN (0.66) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL8229111 | 0.83 | REN (0.68) | RENCYP3A4 | |
| SCHEMBL4348406 | 0.82 | REN (0.51) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL4348403 | 0.82 | REN (0.51) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2931195 | 0.80 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2985802 | 0.80 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2936894 | 0.80 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL8223336 | 0.79 | REN (0.52) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL4885174 | 0.77 | REN (0.44) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL4885176 | 0.77 | REN (0.44) | RENCYP3A4HTR1AADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281161-A1 | Organic Compounds | MAIBAUM JUERGEN KLAUS | 2009-11-12 | — | — | US | disclosed |
| US-20090281161-A1 | Organic Compounds | MAIBAUM JUERGEN KLAUS | 2009-11-12 | — | — | US | disclosed |
| US-20090281161-A1 | Organic Compounds | MAIBAUM JUERGEN KLAUS | 2009-11-12 | — | — | US | disclosed |
| EP-2054407-A2 | PYROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | Novartis AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2007144129-A2 | PYRROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281161-A1 | Organic Compounds | REN, ACE, OTC | REN 1/4885CYP3A4 173/4885HTR1A 2983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.