Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 4/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971163 | 0.77 | ADORA2A (0.41) | ADORA2AMAP2K3IKBKBCAMKK2CAMKK1 | |
| SCHEMBL16741044 | 0.76 | OPRM1 (0.34) | CAMKK2IDO1 | |
| SCHEMBL23067310 | 0.76 | MAP2K3 (0.50) | ADORA2AMAP2K3IKBKBMAP2MAP2K1 | |
| SCHEMBL2848953 | 0.76 | ADORA2A (0.46) | ADORA2AMAP2K3IKBKBMAP2MAP2K1 | |
| SCHEMBL9206473 | 0.76 | CNR1 (0.36) | CAMKK2IDO1KDM4E | |
| SCHEMBL32683865 | 0.75 | OPRM1 (0.43) | IDO1KDM4E | |
| SCHEMBL2241353 | 0.74 | HCRTR1 (0.43) | KDM4E | |
| SCHEMBL978876 | 0.74 | IKBKB (0.33) | ADORA2AIKBKBCAMKK2CAMKK1MAP2 | |
| Formamide SCHEMBL29058737 | 0.72 | ADORA2A (0.42) | ADORA2AMAP2K3IKBKBMAP2MAP2K1 | |
| SCHEMBL12495395 | 0.72 | KDM4E (0.47) | ADORA2AMAP2K3IKBKBMAP2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |