Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29959318 | 0.94 | ADORA2A (0.39) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| SCHEMBL945837 | 0.89 | HPGDS (0.49) | IKBKBCHEK2MKNK1HPGDS | |
| SCHEMBL3971167 | 0.77 | ADORA2A (0.41) | ADORA2AMAP2K3IKBKBKDM4ECHUK | |
| SCHEMBL23067311 | 0.76 | MAP2K3 (0.50) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| SCHEMBL2848953 | 0.76 | ADORA2A (0.46) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| SCHEMBL16741044 | 0.76 | OPRM1 (0.34) | CAMKK2GSK3B | |
| SCHEMBL30423145 | 0.75 | ADORA2A (0.45) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| SCHEMBL231896 | 0.73 | MKNK1 (0.56) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| Formamide SCHEMBL29058737 | 0.72 | ADORA2A (0.42) | ADORA2ABCAT2MAP2K3IKBKBKDM4E | |
| SCHEMBL31253002 | 0.71 | MEN1 (0.40) | ADORA2ABCAT2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |