Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964361 | 0.90 | CYP3A4 (0.36) | PTGDR2RAPGEF4 | |
| SCHEMBL3971663 | 0.89 | PTGDR2 (0.45) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3970095 | 0.87 | RAPGEF4 (0.43) | PTGDR2PTGDRRAPGEF4PTGESALOX5 | |
| SCHEMBL13881864 | 0.87 | PTGDR2 (0.41) | PTGDR2PTGDRRAPGEF4ALDH1A1EGLN1 | |
| SCHEMBL3968730 | 0.87 | PTGDR2 (0.42) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3964356 | 0.85 | PTGDR2 (0.39) | PTGDR2PTGDRRAPGEF4EGLN1HTR6 | |
| SCHEMBL3972665 | 0.84 | PTGDR2 (0.38) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3974788 | 0.84 | PTGDR2 (0.46) | PTGDR2PTGDRRAPGEF4 | |
| SCHEMBL3966242 | 0.83 | PTGDR2 (0.38) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3969343 | 0.82 | PTGDR2 (0.39) | PTGDR2PTGDRRAPGEF4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |