Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | PPME1 | Q9Y570 | 4/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.35 |
| ▸ | APEH | P13798 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968730 | 0.96 | PTGDR2 (0.42) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3974788 | 0.93 | PTGDR2 (0.46) | PTGDR2PTGDRPPME1RAPGEF4 | |
| SCHEMBL3970095 | 0.93 | RAPGEF4 (0.43) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3972665 | 0.92 | PTGDR2 (0.38) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3966242 | 0.92 | PTGDR2 (0.38) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3964356 | 0.91 | PTGDR2 (0.39) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3969343 | 0.91 | PTGDR2 (0.39) | PTGDR2PTGDRHTR6PPME1RAPGEF4 | |
| SCHEMBL3973994 | 0.91 | PTGDR2 (0.40) | PTGDR2HTR6PPME1RAPGEF4APEH | |
| SCHEMBL3971500 | 0.89 | PTGDR2 (0.39) | PTGDR2PTGDRHTR6RAPGEF4 | |
| SCHEMBL3968885 | 0.86 | PPME1 (0.37) | PTGDR2HTR6PPME1RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |