Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389023 | 0.81 | HPGD (0.35) | HTTHPGDEGFRALDH1A1LMNA | |
| SCHEMBL406036 | 0.80 | MRGPRX4 (0.39) | HTTHPGDALDH1A1GAAMAPT | |
| SCHEMBL13968706 | 0.77 | HPGD (0.38) | HTTHPGDPDK1PDK2PDK3 | |
| SCHEMBL1397668 | 0.72 | HPGD (0.41) | HTTHPGDALDH1A1LMNAMAPT | |
| SCHEMBL3932786 | 0.69 | HPGD (0.41) | HTTHPGDALDH1A1LMNAMAPT | |
| SCHEMBL404545 | 0.67 | ALDH1A1 (0.43) | HTTHPGDALDH1A1GAALMNA | |
| SCHEMBL22279549 | 0.65 | HPGD (0.50) | HTTHPGDGAAMAPTNPC1 | |
| SCHEMBL22990771 | 0.65 | CYP17A1 (0.44) | HTTEGFRLMNAPOLBAPEX1 | |
| SCHEMBL29697261 | 0.65 | CYP17A1 (0.44) | HTTEGFRLMNAPOLBAPEX1 | |
| SCHEMBL2353023 | 0.65 | AAK1 (0.40) | HTTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007259-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007259-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| EP-2011783-A1 | Process for the preparation of an indole derivative | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | IDO1, IDO2, TPH1 | PGK1 557/4885HTT 1448/4885HPGD 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.