Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12794646 | 1.00 | CHRM2 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL3971648 | 1.00 | CHRM2 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL13767944 | 0.95 | CHRM2 (0.51) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL6945483 | 0.86 | OPRM1 (0.64) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL3971681 | 0.84 | ALDH1A1 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL12794645 | 0.84 | ALDH1A1 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL5352082 | 0.84 | KCNH2 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL5352080 | 0.84 | KCNH2 (0.56) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL20483452 | 0.82 | CHRM2 (0.64) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL13767943 | 0.81 | KCNH2 (0.53) | CHRM2CHRM4CHRM5KCNH2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682142-B1 | M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| US-7906531-B2 | M3 muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2011-03-15 | — | — | US | disclosed |
| US-20090275604-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | GLAXO GROUP LIMITED | 2009-11-05 | — | — | US | disclosed |
| US-7563803-B2 | M3 muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2009-07-21 | — | — | US | disclosed |
| US-7439255-B2 | Muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2008-10-21 | — | — | US | disclosed |
| US-20070270456-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | GLAXO GROUP LIMITED | 2007-11-22 | — | — | US | disclosed |
| US-20070129396-A1 | Muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129396-A1 | Muscarinic acetylcholine receptor antagonists | CHRM3, CHRNG, CHRM2 | CHRM2 3/4885CHRM4 8/4885CHRM5 4/4885 |
| US-20090275604-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | CHRM3, CHRM2, CHRM5 | CHRM2 2/4885CHRM4 6/4885CHRM5 3/4885 |
| US-20070270456-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | CHRM3, CHRM2, CHRM5 | CHRM2 2/4885CHRM4 6/4885CHRM5 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.