Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.50 |
| ▸ | CHUK | O15111 | 9/20 | 0.50 |
| ▸ | IKBKG | Q9Y6K9 | 9/20 | 0.50 |
| ▸ | VCP | P55072 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969427 | 0.90 | IKBKB (0.53) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| Hydrochloric Acid SCHEMBL3961561 | 0.89 | IKBKB (0.52) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| Hydrochloric Acid SCHEMBL3961613 | 0.85 | IKBKB (0.51) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| SCHEMBL3971739 | 0.83 | VCP (0.46) | VCPSLC2A1DRD2DRD3 | |
| SCHEMBL3963258 | 0.79 | MKNK1 (0.46) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| SCHEMBL4075976 | 0.77 | MKNK1 (0.45) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| SCHEMBL3971664 | 0.76 | SRC (0.47) | IKBKBCHUKIKBKGMKNK1CDK4 | |
| SCHEMBL3961990 | 0.76 | FGFR1 (0.49) | MKNK1PRKCZ | |
| SCHEMBL3958666 | 0.76 | MKNK1 (0.47) | MKNK1CDK4GSK3BDRD2DRD3 | |
| SCHEMBL13799539 | 0.75 | IKBKB (0.56) | IKBKBCHUKIKBKGMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |