Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963837 | 0.91 | FGFR1 (0.44) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL3965330 | 0.90 | SLC2A1 (0.43) | SLC2A1DRD2DRD3HTR2AHRH3 | |
| SCHEMBL3971053 | 0.90 | SLC2A1 (0.43) | SLC2A1DRD2DRD3ACHEHTR2A | |
| SCHEMBL3969374 | 0.87 | LCK (0.41) | DYRK2DRD2DRD3HRH3FGFR1 | |
| SCHEMBL3962260 | 0.83 | IKBKB (0.50) | VCPSLC2A1DRD2DRD3 | |
| SCHEMBL3962142 | 0.81 | ACKR3 (0.55) | DYRK2DRD2DRD3FGFR1DRD4 | |
| Hydrochloric Acid SCHEMBL3964380 | 0.81 | TACR2 (0.38) | DRD2HTR2AHRH3FGFR1SRC | |
| SCHEMBL3964127 | 0.80 | FGFR1 (0.44) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL3966578 | 0.80 | FGFR1 (0.50) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL3965524 | 0.80 | SLC2A1 (0.42) | SLC2A1DRD2HTR2AFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-B1 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |