Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | VNN1 | O95497 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190875 | 0.86 | MAPT (0.64) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL8055544 | 0.81 | MAPT (0.45) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL3980734 | 0.75 | ALDH1A1 (0.46) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL20511185 | 0.74 | APP (0.48) | LMNAKDM4CFFAR1FFAR4HIF1A | |
| SCHEMBL16110725 | 0.73 | ALDH1A1 (0.51) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL8051447 | 0.73 | MAPT (0.42) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL8057329 | 0.71 | HRH1 (0.48) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL23440281 | 0.71 | POLB (0.59) | MEN1LMNAMAPK1KMT2ANPC1 | |
| SCHEMBL22191121 | 0.70 | ALDH1A1 (0.49) | MAPTKDM4EMEN1LMNAHPGD | |
| SCHEMBL18664427 | 0.70 | AOC3 (0.53) | MAPTLMNAALDH1A1KDM4CFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |