Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971763 | 0.81 | MAPT (0.50) | MAPTNPC1RAB9ARECQLMEN1 | |
| SCHEMBL22190875 | 0.80 | MAPT (0.64) | MAPTNPC1RAB9ARECQLMEN1 | |
| SCHEMBL8051447 | 0.74 | MAPT (0.42) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL12895544 | 0.73 | MAPT (0.54) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL18904116 | 0.72 | ALDH1A1 (0.41) | NPC1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL22191121 | 0.71 | ALDH1A1 (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL27401621 | 0.70 | MAPT (0.50) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL6756121 | 0.69 | RAPGEF4 (0.44) | MAPTLMNAALDH1A1CYP1A2TSHR | |
| SCHEMBL16110725 | 0.68 | ALDH1A1 (0.51) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL166894 | 0.67 | TP53 (0.61) | MAPTNPC1RAB9ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |