Pyruvate

Pyruvate

SCHEMBL3972101

CC(=O)C(=O)O.O=CCO

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
SLC15A2 Q16348 1/20 0.36
FFAR3 O14843 2/20 0.35
TSHR P16473 1/20 0.35
THPO P40225 1/20 0.35
LCK P06239 1/20 0.35
FYN P06241 1/20 0.35
OR51E2 Q9H255 2/20 0.33
EGLN1 Q9GZT9 3/20 0.32
ALDH1A1 P00352 3/20 0.32
MAPK1 P28482 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
ALKBH5 Q6P6C2 1/20 0.32
SUCNR1 Q9BXA5 1/20 0.32
KDM4E B2RXH2 1/20 0.31
KDM6B O15054 1/20 0.31
KDM5C P41229 1/20 0.31
PHF8 Q9UPP1 1/20 0.31
KDM2A Q9Y2K7 1/20 0.31
SLC13A3 Q8WWT9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28585842 0.87
Acetic Acid SCHEMBL9165534 0.87 FFAR3 (0.50) LMNASLC15A2FFAR3TSHRTHPO
Acetic Acid SCHEMBL28585841 0.81 FFAR3 (0.44) LMNASLC15A2FFAR3TSHRLCK
Pyruvate SCHEMBL659654 0.79 TSHR (0.41) FFAR3TSHRTHPOLCKFYN
Pyruvate SCHEMBL27831035 0.79 TSHR (0.41) FFAR3TSHRTHPOLCKFYN
Pyruvate SCHEMBL5693024 0.77 ALDH1A1 (0.43) LMNASLC15A2FFAR3TSHRTHPO
Pyruvate SCHEMBL27849498 0.76
Pyruvate SCHEMBL386478 0.76
Pyruvate SCHEMBL2404785 0.76
Pyruvate SCHEMBL23829857 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105441372-A Recombinant corynebacterium glutamicum and application UNIV TSINGHUA 2016-03-30 CN disclosed
CN-101512004-A Microbial synthesis of D-1,2,4-butanetriol UNIV MICHIGAN STATE (US) 2009-08-19 CN disclosed
EP-2054518-A2 MICROBIAL SYNTHESIS OF D-1,2,4-BUTANETRIOL Board of Trustees of Michigan State University (US) 2009-05-06 EP disclosed
WO-2008091288-A2 MICROBIAL SYNTHESIS OF D-1,2,4-BUTANETRIOL BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2008-07-31 WO disclosed