Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5983412 | 0.88 | PTPN1 (0.73) | PTPN1SIRT3 | |
| SCHEMBL3970308 | 0.88 | PTPN1 (0.73) | PTPN1SIRT3 | |
| SCHEMBL3972664 | 0.85 | PTPN1 (0.70) | PTPN1SIRT3NR1H4EYA3KDM5A | |
| SCHEMBL3973517 | 0.83 | PTPN1 (0.66) | PTPN1SIRT3NR1H4EYA3CYP2C9 | |
| SCHEMBL5987451 | 0.83 | SIRT3 (0.54) | PTPN1SIRT3NR1H4EYA3KDM5A | |
| SCHEMBL31314642 | 0.83 | SIRT3 (0.64) | PTPN1SIRT3NR1H4EYA3KDM5A | |
| SCHEMBL3968618 | 0.81 | SIRT3 (0.57) | PTPN1SIRT3NR1H4EYA3KDM5A | |
| SCHEMBL3974575 | 0.81 | PTPN1 (0.64) | PTPN1SIRT3 | |
| SCHEMBL3971819 | 0.78 | SIRT3 (0.51) | PTPN1SIRT3MAPTNR1H4EYA3 | |
| SCHEMBL3973525 | 0.76 | PTPN1 (0.48) | PTPN1SIRT3NR1H4EYA3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534894-B2 | Biphenyloxy-acids | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060020003-A1 | Biphenyloxy-acids | WYETH (US) | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020003-A1 | Biphenyloxy-acids | AHR, ARNT, NR1H4 | PTPN1 1495/4885SIRT3 2700/4885TP53 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.