SCHEMBL3972328

SCHEMBL3972328

NCCc1ccc(O)cc1F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.54
CHRNA7 P36544 1/20 0.53
TYR P14679 1/20 0.52
RECQL P46063 3/20 0.50
KMT2A Q03164 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
MEN1 O00255 2/20 0.50
RAD52 P43351 2/20 0.50
BLM P54132 2/20 0.50
GAPDH P04406 1/20 0.50
THRB P10828 1/20 0.50
APEX1 P27695 1/20 0.50
HTR2C P28335 3/20 0.49
HTR1A P08908 3/20 0.49
HTR2A P28223 2/20 0.49
HTR2B P41595 2/20 0.49
HTR3A P46098 2/20 0.49
DRD1 P21728 2/20 0.49
HTR3E A5X5Y0 1/20 0.49
HTR3B O95264 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29465001 0.84 TYR (0.74) TAAR1TYRRECQLKMT2ATDP1
SCHEMBL632515 0.84 TYR (0.74) TAAR1TYRRECQLKMT2ATDP1
SCHEMBL14446348 0.84 TYR (0.48) TAAR1CHRNA7TYR
Hydrochloric Acid SCHEMBL5355571 0.83 TYR (0.46) TAAR1CHRNA7TYRRECQLKMT2A
SCHEMBL15130521 0.83 TAAR1 (0.50) TAAR1TYRRECQLKMT2ATDP1
Hydrochloric Acid SCHEMBL29065992 0.83 TYR (0.71) TAAR1TYRRECQLKMT2ATDP1
SCHEMBL2767004 0.83 CHRNA7 (0.53) TAAR1CHRNA7TYRKMT2ATDP1
SCHEMBL6576435 0.81 CHRNA7 (0.56) CHRNA7TYRKMT2ATDP1MEN1
SCHEMBL2766520 0.81 CHRNA7 (0.51) TAAR1CHRNA7TYRKMT2ATDP1
SCHEMBL27814767 0.81 TYR (0.55) CHRNA7TYRKMT2ATDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
WO-2009055077-A1 TROPANE COMPOUNDS EXELIXIS, INC. (US) 2009-04-30 WO disclosed
WO-2005021472-A2 FLUORIDATION OF ELECTRON RICH AROMATIC SYSTEMS IC INNOVATIONS LIMITED (GB) 2005-03-10 WO disclosed
EP-0163948-B1 PROCESS FOR PRODUCING AN INDOLINE IHARA CHEMICAL IND CO 1989-08-16 EP disclosed
US-4673749-A CYCLIZATION OF 2-HOLOGENO PHENETHYLAMINES WITH COPPER CATALYS T AND ALKALI DEHYROHALOGENATING AGENT IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1987-06-16 US disclosed
EP-0163948-A1 Process for producing an indoline IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1985-12-11 EP disclosed
US-4280958-A COPPER-TYPE CATALYST USED IN CYCLIZATION OF A HALOGENOPHENETHYLAMINE IN THE PRESENCE OF AN AMINE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1981-07-28 US disclosed
US-4159271-A CYCLIZATION OF A 2-HALOGENOPHENETHYLAMINE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1979-06-26 US disclosed