Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.64 |
| ▸ | LTA4H | P09960 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1730306 | 0.86 | LTA4H (0.77) | KCNA5LTA4HDRD3DRD2HRH1 | |
| SCHEMBL5480208 | 0.85 | KCNA5 (0.74) | KCNA5LTA4HDRD3DRD2HRH1 | |
| SCHEMBL23301248 | 0.85 | KCNA5 (0.58) | KCNA5LTA4HDRD3DRD2ALDH1A1 | |
| SCHEMBL19462784 | 0.85 | DRD3 (0.79) | KCNA5DRD3DRD2 | |
| SCHEMBL6034033 | 0.85 | KCNA5 (0.64) | KCNA5LTA4HDRD3DRD2HRH1 | |
| SCHEMBL11336991 | 0.83 | HRH2 (0.78) | HRH1HRH2ALDH1A1 | |
| SCHEMBL11336995 | 0.83 | HRH2 (0.78) | HRH1HRH2ALDH1A1 | |
| SCHEMBL2236459 | 0.82 | HRH3 (0.57) | — | |
| SCHEMBL1730771 | 0.81 | HRH2 (0.58) | KCNA5LTA4HDRD3DRD2HRH1 | |
| SCHEMBL3871235 | 0.81 | CACNA2D1 (0.60) | KCNA5LTA4HDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1988902-A4 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-05-06 | — | — | EP | disclosed |
| EP-1988902-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007097871-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-30 | — | — | WO | disclosed |