Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | DRD1 | P21728 | 3/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD5 | P21918 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698800 | 0.94 | USP2 (0.73) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL1730768 | 0.93 | USP2 (0.71) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL15679705 | 0.93 | USP2 (0.82) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL5568615 | 0.91 | LTA4H (0.67) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL13698801 | 0.91 | LTA4H (0.87) | LTA4HMEN1LMNAHTTKMT2A | |
| SCHEMBL1728918 | 0.90 | USP2 (0.78) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL4174980 | 0.88 | LTA4H (0.71) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL1730302 | 0.88 | LTA4H (0.63) | LTA4HUSP2ALDH1A1HPGDMEN1 | |
| SCHEMBL19560190 | 0.88 | LTA4H (0.67) | LTA4HUSP2ALDH1A1LMNAHRH3 | |
| SCHEMBL1730763 | 0.88 | LTA4H (0.67) | LTA4HUSP2ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1988902-B1 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | disclosed |
| EP-1988902-A4 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-05-06 | — | — | EP | disclosed |
| EP-1988902-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007097871-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | SIGMAR1, OPRL1, OPRK1 | LTA4H 2891/4885USP2 3002/4885ALDH1A1 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.