Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224162 | 0.79 | KMT2A (0.38) | CTNNB1PARP10SMN1; SMN2MEN1NPC1 | |
| SCHEMBL5216616 | 0.75 | KMT2A (0.36) | CTNNB1PARP10SMN1; SMN2MEN1NPC1 | |
| SCHEMBL27605287 | 0.72 | SMN1; SMN2 (0.45) | CTNNB1SMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL16291648 | 0.72 | BRD4 (0.53) | PARP10SMN1; SMN2MAPTKMT2ABRD4 | |
| SCHEMBL11098348 | 0.71 | KMT2A (0.41) | SMN1; SMN2MEN1NPC1MAPTRAB9A | |
| SCHEMBL27680126 | 0.71 | CTNNB1 (1.00) | CTNNB1PARP10SMN1; SMN2MEN1MAPT | |
| SCHEMBL5724 | 0.71 | CTNNB1 (1.00) | CTNNB1PARP10SMN1; SMN2MEN1MAPT | |
| SCHEMBL28876495 | 0.71 | CTNNB1 (1.00) | CTNNB1PARP10SMN1; SMN2MEN1MAPT | |
| Diphenylether SCHEMBL10618785 | 0.70 | PARP10 (0.71) | CTNNB1PARP10SMN1; SMN2KMT2ATSHR | |
| Diphenylether SCHEMBL8165466 | 0.70 | PARP10 (0.71) | CTNNB1PARP10SMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049421-A1 | COMPOSITIONS AND METHODS FOR ENHANCING ENZYME ACTIVITY IN GAUCHER, GM1-GANGLIOSIDOSIS/MORQUIO B DISEASE, AND PARKINSON'S DISEASE | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009049422-A1 | COMPOSITIONS AND METHODS FOR ENHANCING ENZYME ACTIVITY IN GAUCHER, GM1 -GANGLIOSIDOSIS/MORQUIO B DISEASE. AND PARKINSON'S DISEASE | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-04-23 | — | — | WO | disclosed |