Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.59 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27946675 | 0.87 | JAK2 (0.77) | TYK2SMN1; SMN2HTTJAK2L3MBTL1 | |
| SCHEMBL21993 | 0.85 | HPGD (1.00) | TYK2HPGDSMN1; SMN2HTTL3MBTL1 | |
| Iodomethane SCHEMBL20530190 | 0.82 | HPGD (0.93) | TYK2HPGDSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL3684485 | 0.82 | HPGD (0.79) | TYK2HPGDSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL29519361 | 0.82 | HPGD (0.79) | TYK2HPGDSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL13162689 | 0.82 | ALDH1A1 (0.70) | TYK2HPGDHTTALDH1A1MAPK1 | |
| SCHEMBL11781486 | 0.81 | HPGD (0.77) | TYK2HPGDSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL12700205 | 0.81 | ALDH1A1 (0.76) | TYK2SMN1; SMN2HTTJAK2L3MBTL1 | |
| SCHEMBL30192798 | 0.80 | TYK2 (0.67) | TYK2SMN1; SMN2JAK2L3MBTL1ALDH1A1 | |
| SCHEMBL13322124 | 0.80 | TYK2 (0.67) | TYK2HPGDSMN1; SMN2HTTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101501035-B | Pyrimidine derivatives as PI3K inhibitors and uses thereof | CHUGAI PHARMACEUTICAL CO LTD | 2013-01-23 | — | — | CN | disclosed |
| CN-101501035-A | Pyrimidine derivatives as P13K inhibitors and uses thereof | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |
| WO-2009049422-A1 | COMPOSITIONS AND METHODS FOR ENHANCING ENZYME ACTIVITY IN GAUCHER, GM1 -GANGLIOSIDOSIS/MORQUIO B DISEASE. AND PARKINSON'S DISEASE | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009049421-A1 | COMPOSITIONS AND METHODS FOR ENHANCING ENZYME ACTIVITY IN GAUCHER, GM1-GANGLIOSIDOSIS/MORQUIO B DISEASE, AND PARKINSON'S DISEASE | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-04-23 | — | — | WO | disclosed |