Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | MC5R | P33032 | 2/20 | 0.43 |
| ▸ | MC3R | P41968 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971600 | 0.85 | SIGMAR1 (0.52) | BCHESIGMAR1CYP1A2CYP2A6MC4R | |
| SCHEMBL15701722 | 0.82 | BCHE (0.58) | BCHESIGMAR1CYP1A2OPRD1OPRK1 | |
| SCHEMBL9520781 | 0.79 | SIGMAR1 (0.62) | BCHESIGMAR1CYP1A2CYP2A6HTR2A | |
| SCHEMBL8082126 | 0.79 | AOC3 (0.47) | BCHESIGMAR1CYP1A2OPRD1OPRK1 | |
| SCHEMBL8075773 | 0.77 | OPRK1 (0.46) | BCHEOPRD1OPRK1SLC6A2SLC6A4 | |
| SCHEMBL29286752 | 0.75 | BCHE (1.00) | BCHESIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14024617 | 0.75 | SIGMAR1 (0.54) | BCHESIGMAR1CYP1A2OPRD1OPRK1 | |
| SCHEMBL9523589 | 0.75 | SIGMAR1 (0.55) | BCHESIGMAR1CYP1A2CYP2A6HTR2A | |
| SCHEMBL12153268 | 0.74 | BCHE (0.56) | BCHESIGMAR1CYP1A2CYP2A6HTR2A | |
| SCHEMBL13025061 | 0.74 | AOC3 (0.48) | CYP1A2OPRD1OPRK1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3801476-A2 | METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS | Kartos Therapeutics, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| WO-2010104406-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-09-16 | — | — | WO | disclosed |
| WO-2009051661-A2 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2009-04-23 | — | — | WO | disclosed |