Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148348 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HSD17B10MEN1GAAKMT2A | |
| SCHEMBL1148222 | 0.82 | ALDH1A1 (0.36) | ALDH1A1HSD17B10MEN1GAAKMT2A | |
| SCHEMBL4413496 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HSD17B10MEN1GAAKMT2A | |
| SCHEMBL1148721 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL1148436 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HSD17B10MEN1POLBKMT2A | |
| SCHEMBL1148697 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MEN1GAAKMT2A | |
| SCHEMBL1148597 | 0.78 | MCL1 (0.36) | ALDH1A1HSD17B10MEN1POLBKMT2A | |
| SCHEMBL1148311 | 0.78 | KCNMA1 (0.46) | ALDH1A1HSD17B10MEN1POLBKMT2A | |
| SCHEMBL1148642 | 0.77 | MAPT (0.41) | ALDH1A1HSD17B10MEN1POLBGAA | |
| SCHEMBL1148329 | 0.77 | ALDH1A1 (0.37) | ALDH1A1HSD17B10MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |