Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 20/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980311 | 0.94 | NR3C1 (0.69) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4407495 | 0.91 | NR3C1 (0.56) | NR3C1 | |
| SCHEMBL3973005 | 0.90 | NR3C1 (0.74) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL476788 | 0.87 | NR3C1 (0.83) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13884686 | 0.87 | NR3C1 (0.57) | NR3C1 | |
| SCHEMBL4410075 | 0.85 | NR3C1 (0.61) | NR3C1 | |
| SCHEMBL3974058 | 0.85 | NR3C1 (0.75) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13884927 | 0.85 | NR3C1 (0.66) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13885277 | 0.84 | NR3C1 (0.65) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13884601 | 0.83 | NR3C1 (0.73) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050243-A1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050243-A1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |