Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.67 |
| ▸ | F2 | P00734 | 7/20 | 0.67 |
| ▸ | F7 | P08709 | 5/20 | 0.51 |
| ▸ | F10 | P00742 | 4/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.51 |
| ▸ | F12 | P00748 | 3/20 | 0.51 |
| ▸ | F9 | P00740 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.50 |
| ▸ | KLK1 | P06870 | 5/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436567 | 0.86 | F11 (0.63) | F11F2F7F10PRSS1 | |
| SCHEMBL7702655 | 0.86 | F11 (0.65) | F11F2F7F10PRSS1 | |
| Hydrochloric Acid SCHEMBL3758536 | 0.85 | F11 (0.62) | F11F2F7F10PRSS1 | |
| SCHEMBL6434959 | 0.85 | F11 (0.66) | F11F2F7F10PRSS1 | |
| SCHEMBL7708352 | 0.85 | F11 (0.66) | F11F2F7F10PRSS1 | |
| SCHEMBL24645591 | 0.84 | F11 (0.63) | F11F2F7F10PRSS1 | |
| SCHEMBL21429784 | 0.84 | F11 (0.63) | F11F2F7F10PRSS1 | |
| SCHEMBL7425365 | 0.84 | F11 (0.56) | F11F2F7F10PRSS1 | |
| SCHEMBL7711114 | 0.84 | F11 (0.62) | F11F2F7F10PRSS1 | |
| SCHEMBL6436658 | 0.84 | F11 (0.62) | F11F2F7F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511816-B | Aminoisoquinoline thrombin inhibitors with improved bioavailability | ORGANON NV | 2013-01-02 | — | — | CN | disclosed |
| CN-101511816-A | Aminoisoquinoline thrombin inhibitors with improved bioavailability | ORGANON NV (NL) | 2009-08-19 | — | — | CN | disclosed |
| EP-2054402-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. Organon (NL) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008017650-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON (NL) | 2008-02-14 | — | — | WO | disclosed |