Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 12/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431340 | 0.74 | CYP2C19 (0.47) | LMNAELANETSHR | |
| SCHEMBL29607284 | 0.69 | ELANE (0.74) | LMNAELANE | |
| SCHEMBL13357769 | 0.68 | SIGMAR1 (0.46) | — | |
| SCHEMBL29954632 | 0.66 | SIGMAR1 (0.39) | LMNA | |
| SCHEMBL8380679 | 0.66 | POLB (0.43) | ELANE | |
| SCHEMBL28197586 | 0.66 | ELANE (0.70) | ELANEL3MBTL1 | |
| SCHEMBL28246707 | 0.65 | ALDH1A1 (0.60) | LMNAMAPK1L3MBTL1 | |
| SCHEMBL3150572 | 0.65 | ELANE (0.57) | LMNAELANE | |
| SCHEMBL11315487 | 0.65 | ELANE (0.61) | LMNAELANEMAPK1L3MBTL1TSHR | |
| SCHEMBL353268 | 0.65 | NOTUM (0.51) | LMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |