SCHEMBL3973933

SCHEMBL3973933

O=C(C(=O)c1ccnc(F)c1)c1ccc(F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 5/20 0.59
CES2 O00748 4/20 0.59
LTA4H P09960 1/20 0.48
KMT2A Q03164 1/20 0.43
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
PFKFB3 Q16875 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
KDM5A P29375 1/20 0.39
KDM2B Q8NHM5 1/20 0.39
KDM4C Q9H3R0 1/20 0.39
KDM5B Q9UGL1 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
BCL2L1 Q07817 1/20 0.38
BAD Q92934 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2847108 0.84 LTA4H (0.41) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL2847107 0.84 LTA4H (0.41) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL830162 0.84 CES2 (0.44) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL828659 0.84 CES2 (0.44) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL828398 0.84 CES2 (0.44) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL10080304 0.82 CES1 (0.55) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL9953768 0.82 CES1 (0.55) CES1CES2LTA4HKMT2ACA1
SCHEMBL4092549 0.79 CYP2C19 (0.40) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL4092551 0.79 CYP2C19 (0.40) CES1CES2LTA4HKMT2ATAS1R3
SCHEMBL3053668 0.78 LTA4H (0.76) CES1CES2LTA4HKMT2ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054404-A1 IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT MERCKLE GMBH (DE) 2009-05-06 EP disclosed
WO-2008023066-A1 IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT MERCKLE GMBH (DE) 2008-02-28 WO disclosed
EP-1853581-A1 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS MERCKLE GMBH (DE) 2007-11-14 EP disclosed
WO-2006089798-A1 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS MERCKLE GMBH (DE) 2006-08-31 WO disclosed