Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 4/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883515 | 0.91 | TTK (0.45) | KDRJAK3JAK2PTK2AURKA | |
| SCHEMBL13883581 | 0.86 | KDR (0.41) | KDRCDK1JAK3JAK2PTK2 | |
| SCHEMBL3974734 | 0.84 | KDR (0.46) | KDRCDK1JAK3JAK2PTK2 | |
| SCHEMBL3973909 | 0.77 | TTK (0.58) | JAK3JAK2PTK2JAK1LRRK2 | |
| SCHEMBL3975392 | 0.76 | PDPK1 (0.43) | KDRCDK1JAK3JAK2JAK1 | |
| SCHEMBL13883504 | 0.75 | TTK (0.45) | KDRJAK3JAK2PTK2AURKA | |
| SCHEMBL3970857 | 0.75 | TTK (0.45) | KDRJAK3JAK2PTK2AURKA | |
| SCHEMBL3971647 | 0.74 | PDPK1 (0.47) | KDRJAK3JAK2PTK2AURKA | |
| Hydrochloric Acid SCHEMBL3974362 | 0.74 | TTK (0.44) | KDRJAK3JAK2PTK2AURKA | |
| SCHEMBL4073485 | 0.74 | TTK (0.47) | KDRJAK3JAK2PTK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |