Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.56 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | TLR2 | O60603 | 1/20 | 0.48 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346236 | 0.87 | MC4R (0.65) | MC4RPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL19403679 | 0.82 | MEN1 (0.51) | SIGMAR1POLBTLR2TLR1ALDH1A1 | |
| SCHEMBL17117337 | 0.79 | SIGMAR1 (0.63) | SIGMAR1TAAR1GAAALDH1A1 | |
| SCHEMBL17117412 | 0.78 | ALDH1A1 (0.64) | SIGMAR1TAAR1TLR2TLR1ALDH1A1 | |
| SCHEMBL22607767 | 0.77 | MC4R (0.70) | MC4RPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL22622441 | 0.77 | MC4R (0.70) | MC4RPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL22179105 | 0.77 | MC4R (0.70) | MC4RPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL1799448 | 0.76 | KCNH2 (0.49) | SIGMAR1POLBGAAALDH1A1EPHX2 | |
| SCHEMBL1796938 | 0.76 | KCNH2 (0.49) | SIGMAR1POLBGAAALDH1A1EPHX2 | |
| SCHEMBL9939592 | 0.76 | TAAR1 (0.64) | MC4RTAAR1POLBGAATLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021330-A2 | BENZIMIDAZOLE MODULATORS OF VR1 | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007130780-A2 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-15 | — | — | WO | disclosed |