Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 4/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977037 | 0.94 | POLB (0.53) | POLBSLC2A1KMT5AKDM4EKMT2A | |
| SCHEMBL3974654 | 0.88 | ACP1 (0.54) | POLBSLC2A1KMT5AKDM4EKMT2A | |
| SCHEMBL3973396 | 0.85 | TLR9 (0.56) | POLBSLC2A1KMT5AKDM4EALDH1A1 | |
| SCHEMBL3973975 | 0.84 | CCR4 (0.60) | POLBSLC2A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3972870 | 0.83 | SLC2A1 (0.70) | POLBSLC2A1KMT2ASMN1; SMN2FLT3 | |
| SCHEMBL6668789 | 0.83 | POLB (0.62) | POLBSLC2A1KMT2AFLT3ALDH1A1 | |
| SCHEMBL3974901 | 0.82 | SLC2A1 (0.72) | POLBSLC2A1KMT2AFLT3 | |
| SCHEMBL3972349 | 0.79 | TLR9 (0.66) | POLBKMT5AKDM4EALDH1A1MAPT | |
| SCHEMBL7262687 | 0.78 | MEN1 (0.65) | POLBSLC2A1KMT5AKDM4EKMT2A | |
| SCHEMBL3974916 | 0.77 | KDM4E (0.77) | POLBKMT5AKDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | SERPINA3, APOL1, MGAT3 | POLB 4723/4885SLC2A1 1107/4885KMT5A 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.