Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.56 |
| ▸ | RAD52 | P43351 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.54 |
| ▸ | WHR1 | P49842 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 4/20 | 0.51 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.51 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
| ▸ | KMT5A | Q9NQR1 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977037 | 0.89 | POLB (0.53) | TLR9POLBWHR1KDM1ARCOR1 | |
| SCHEMBL3974654 | 0.85 | ACP1 (0.54) | TLR9RAD52POLBWHR1KDM1A | |
| SCHEMBL3974464 | 0.85 | POLB (0.57) | TLR9RAD52POLBKDM1ARCOR1 | |
| SCHEMBL3973275 | 0.81 | RAD52 (0.69) | TLR9RAD52POLBSMARCA2RXFP1 | |
| SCHEMBL3971156 | 0.81 | POLB (0.60) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL3972117 | 0.80 | MEN1 (0.62) | WHR1RXFP1ALDH1A1MAPK1KDM4E | |
| SCHEMBL7268662 | 0.79 | RAD52 (0.51) | TLR9RAD52POLBSMARCA2WHR1 | |
| SCHEMBL3980668 | 0.79 | PGK1 (0.60) | TLR9WHR1ACP1ALDH1A1MAPK1 | |
| SCHEMBL3976872 | 0.79 | MEN1 (0.55) | TLR9WHR1ALDH1A1MAPK1KDM4E | |
| SCHEMBL3975863 | 0.79 | KDM1A (0.49) | RAD52POLBWHR1KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | SERPINA3, APOL1, MGAT3 | TLR9 4215/4885RAD52 4288/4885POLB 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.