SCHEMBL39745

SCHEMBL39745

O=C(O)c1cccc(CCl)n1

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.61
ALOX15 P16050 1/20 0.61
TSHR P16473 1/20 0.61
ACMSD Q8TDX5 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
MRGPRX4 Q96LA9 5/20 0.55
PTGER1 P34995 2/20 0.45
LMNA P02545 1/20 0.44
BRD4 O60885 1/20 0.44
GNE Q9Y223 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31443034 1.00 KDM4E (0.61) KDM4EALOX15TSHRACMSDTDP1
Hydrochloric Acid SCHEMBL28435938 0.98 KDM4E (0.59) KDM4EALOX15TSHRACMSDTDP1
Methyl Alcohol SCHEMBL29028982 0.96 KDM4E (0.57) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL27689596 0.84 CYP1A2 (0.47) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL458194 0.84 MRGPRX4 (0.41) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL31591148 0.83 KDM4E (0.67) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL2352264 0.83 KDM4E (0.67) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL30885081 0.82 NPSR1 (0.43) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL1057937 0.82 NPSR1 (0.43) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL7662023 0.82 KDM4E (0.64) KDM4EALOX15TSHRACMSDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931685-B1 METHOD FOR OBTAINING HIGHLY LUMINESCENT LANTHANIDE COMPLEXES COMMISSARIAT ENERGIE ATOMIQUE (FR) 2011-08-03 EP claimed
US-20080227962-A1 Method for Obtaining Highly Luminescent Lanthanide Complexes COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 2008-09-18 US claimed
EP-1931685-A1 METHOD FOR OBTAINING HIGHLY LUMINESCENT LANTHANIDE COMPLEXES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 2008-06-18 EP claimed
WO-2007031640-A1 METHOD FOR OBTAINING HIGHLY LUMINESCENT LANTHANIDE COMPLEXES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 2007-03-22 WO claimed
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2025-08-05 US disclosed
EP-4377321-A1 METALLO-?-LACTAMASE INHIBITORS University of KwaZulu-Natal (ZA) 2024-06-05 EP disclosed
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS OrsoBio Inc. 2024-02-22 US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 US disclosed
CN-113702536-B Detection method and application of 6-chloromethyl-2-pyridine methanol 佛山奕安赛医药科技有限公司 2023-07-04 CN disclosed
WO-2023007325-A1 METALLO-β-LACTAMASE INHIBITORS UNIVERSITY OF KWAZULU-NATAL (ZA) 2023-02-02 WO disclosed
WO-1999002501-A1 NOVEL COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1999-01-21 WO disclosed
US-4390543-A Substituted pyridine methyl esters of 2-isopropyl-2-(4-chlorophenyl) acetic acid and their use as insecticides MALHOTRA SUDARSHAN K 1983-06-28 US disclosed
US-4262001-A MITICIDES, PARASITICIDES, LARVICIDES THE DOW CHEMICAL COMPANY (US) 1981-04-14 US disclosed
US-4258048-A Substituted pyridine methyl esters of tetramethyl cyclopropane carboxylic acids and their use as insecticides THE DOW CHEMICAL COMPANY (US) 1981-03-24 US disclosed
US-4256893-A INSECTICIDES THE DOW CHEMICAL COMPANY (US) 1981-03-17 US disclosed
US-4228172-A Substituted pyridine methyl esters of 2-isopropyl-2-(4-chlorophenyl)acetic acid and their use as insecticides THE DOW CHEMICAL COMPANY (US) 1980-10-14 US disclosed
US-4221799-A MITICIDES THE DOW CHEMICAL (US) 1980-09-09 US disclosed
US-4163787-A Substituted pyridine methyl esters of cyclopropane carboxylic acids and their use as insecticides THE DOW CHEMICAL COMPANY (US) 1979-08-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 KDM4E 1040/4885ALOX15 1451/4885TSHR 4389/4885
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS ALDH7A1, ACMSD, AMD1 KDM4E 1040/4885ALOX15 1451/4885TSHR 4389/4885
US-20080227962-A1 Method for Obtaining Highly Luminescent Lanthanide Complexes PYM1, C1S, C5 KDM4E 3968/4885ALOX15 1389/4885TSHR 1220/4885
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 KDM4E 1040/4885ALOX15 1451/4885TSHR 4389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.