Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 4/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16673362 | 1.00 | TSHR (0.42) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL11460242 | 0.95 | TSHR (0.37) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL6890254 | 0.95 | TSHR (0.37) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL4014810 | 0.95 | TSHR (0.42) | TSHRTHRBFAAHTRPV1GMNN | |
| SCHEMBL5911729 | 0.93 | TSHR (0.36) | TSHRFAAHTRPV1 | |
| SCHEMBL5066707 | 0.91 | TSHR (0.42) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL4657333 | 0.91 | TSHR (0.42) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL8350454 | 0.88 | TSHR (0.39) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL31634913 | 0.86 | FAAH (0.54) | FAAHTRPV1GMNNUSP2CYP1A2 | |
| SCHEMBL21264913 | 0.86 | FAAH (0.54) | FAAHTRPV1GMNNUSP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |