Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976512 | 0.88 | NAMPT (0.56) | MAPKAPK2LMNAMAPTALDH1A1GAA | |
| SCHEMBL13885939 | 0.85 | CDK1 (0.55) | MAPKAPK2LMNACYP17A1ALDH1A1GAA | |
| SCHEMBL13886030 | 0.83 | ALDH1A1 (0.54) | MAPKAPK2MAPTCYP17A1ALDH1A1GAA | |
| SCHEMBL5925523 | 0.82 | NAMPT (0.56) | MAPKAPK2CYP17A1PTPN11 | |
| SCHEMBL13055402 | 0.82 | CYP17A1 (0.59) | MAPKAPK2CYP17A1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL31300042 | 0.81 | GAA (0.60) | MAPKAPK2LMNAMAPTALDH1A1GAA | |
| SCHEMBL5106835 | 0.81 | CYP17A1 (0.54) | MAPKAPK2MAPTCYP17A1PTPN11 | |
| SCHEMBL31090335 | 0.79 | GAA (0.61) | MAPKAPK2LMNAMAPTCYP17A1ALDH1A1 | |
| SCHEMBL12677009 | 0.78 | CYP17A1 (0.58) | MAPKAPK2CYP17A1ALDH1A1POLB | |
| SCHEMBL16193025 | 0.78 | NAMPT (0.60) | MAPKAPK2MAPTCYP17A1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053448-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009053448-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |