Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978660 | 0.83 | CAMKK2 (0.47) | CSNK1DALDH1A1KDM4EKMT2A | |
| SCHEMBL13109512 | 0.77 | HSP90AB1 (0.56) | SMN1; SMN2JAK3JAK2ALDH1A1HSD17B10 | |
| SCHEMBL13109530 | 0.75 | HSP90AB1 (0.55) | SMN1; SMN2JAK3JAK2ALDH1A1HSD17B10 | |
| SCHEMBL3979141 | 0.75 | BRAF (0.68) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL3322113 | 0.75 | HSP90AB1 (0.69) | SMN1; SMN2ALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL13109609 | 0.74 | HSP90AB1 (0.53) | SMN1; SMN2JAK2ALDH1A1HSD17B10MAPT | |
| SCHEMBL5429822 | 0.73 | SELE (0.54) | SMN1; SMN2JAK3JAK2ALDH1A1HSD17B10 | |
| SCHEMBL13109534 | 0.73 | HSP90AB1 (0.54) | SMN1; SMN2ALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL13109508 | 0.73 | HSP90AB1 (0.51) | SMN1; SMN2ALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL15013911 | 0.72 | JAK3 (0.82) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009059272-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | SMN1; SMN2 4282/4885JAK3 301/4885JAK2 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.