Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30450 | 0.83 | ALDH1A1 (0.37) | PIK3CA | |
| SCHEMBL10210944 | 0.69 | MAPK1 (0.38) | PIK3CDPIK3CA | |
| SCHEMBL15026251 | 0.69 | NPC1 (0.40) | — | |
| SCHEMBL39794 | 0.67 | WNT3A (0.37) | — | |
| SCHEMBL10211443 | 0.66 | MTOR (0.35) | PIK3CDPIK3CA | |
| SCHEMBL10234775 | 0.65 | NPC1 (0.45) | — | |
| SCHEMBL15026288 | 0.64 | PARP10 (0.35) | NTRK1PIK3CA | |
| SCHEMBL30716 | 0.61 | MTOR (0.43) | — | |
| SCHEMBL15026255 | 0.61 | MTOR (0.43) | — | |
| SCHEMBL2725224 | 0.61 | ADORA2A (0.42) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |