Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 13/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418260 | 0.77 | SSTR5 (0.61) | SSTR5HRH1KCNH2HTR2B | |
| SCHEMBL3970950 | 0.74 | SSTR5 (0.39) | SSTR5HRH1KCNH2HTR2BALDH1A1 | |
| SCHEMBL3976467 | 0.72 | KDM4E (0.51) | SSTR5HRH1HTR2BALDH1A1NPSR1 | |
| SCHEMBL3972791 | 0.70 | SSTR5 (0.51) | SSTR5HRH1HTR2BALDH1A1KDM4E | |
| SCHEMBL2421605 | 0.70 | SSTR5 (0.58) | SSTR5HRH1KCNH2HTR2B | |
| SCHEMBL3977762 | 0.70 | SSTR5 (0.52) | SSTR5HRH1HTR2BALDH1A1KDM4E | |
| SCHEMBL4000428 | 0.68 | SSTR5 (0.56) | SSTR5HRH1KCNH2HTR2BALDH1A1 | |
| SCHEMBL3780377 | 0.68 | SSTR5 (0.60) | SSTR5HRH1KCNH2HTR2B | |
| SCHEMBL3939333 | 0.68 | SSTR5 (0.47) | SSTR5HRH1KCNH2HTR2BALDH1A1 | |
| SCHEMBL2417943 | 0.67 | SSTR5 (0.55) | SSTR5HRH1KCNH2HTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |