SCHEMBL3976911

SCHEMBL3976911

Cc1ccncc1CC=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT3 Q9NTG7 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
GABRA1 P14867 1/20 0.38
GABRA5 P31644 1/20 0.38
SOST Q9BQB4 1/20 0.37
HTT P42858 1/20 0.37
CYP2C9 P11712 4/20 0.36
CYP1A2 P05177 3/20 0.36
CYP2E1 P05181 3/20 0.36
CYP3A4 P08684 3/20 0.36
CYP2C8 P10632 3/20 0.36
CYP2D6 P10635 3/20 0.36
CYP2A6 P11509 3/20 0.36
CYP2B6 P20813 3/20 0.36
CYP2C19 P33261 3/20 0.36
NAMPT P43490 1/20 0.35
NOS1 P29475 1/20 0.35
KDM4C Q9H3R0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4057138 0.84 SIRT3 (0.36) SIRT3TDP1HTTCYP2E1CYP2C8
SCHEMBL27510425 0.82 CYP11B1 (0.41) SIRT3TDP1CYP11B1CYP11B2GABRA1
SCHEMBL31336994 0.81 NOS1 (0.39) SIRT3TDP1CYP11B1CYP11B2GABRA1
SCHEMBL23580328 0.81 NOS1 (0.39) SIRT3TDP1CYP11B1CYP11B2GABRA1
SCHEMBL16671024 0.80 CYP2E1 (0.41) CYP2C9CYP1A2CYP2E1CYP3A4CYP2C8
SCHEMBL30335585 0.79
SCHEMBL212818 0.79
SCHEMBL317754 0.77
SCHEMBL30340602 0.76 GAA (0.38) CYP1A2CYP3A4CYP2C19AOC1AOC3
SCHEMBL25170661 0.76 AOC1 (0.44) TDP1CYP2C9CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012162468-A1 THIAZOL DERIVATIVES AS PRO -MATRIX METALLOPROTEINASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2012-11-29 WO disclosed
EP-2056817-A1 BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM Bayer HealthCare AG (DE) 2009-05-13 EP disclosed
WO-2008025509-A1 BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-03-06 WO disclosed
EP-1438046-A4 THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE AGOURON PHARMA (US) 2004-10-20 EP disclosed
EP-1438046-A2 THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE AGOURON PHARMACEUTICALS, INC. (US) 2004-07-21 EP disclosed
WO-2003027096-A1 SUBSTITUTED 3-PYRIDYL IMIDAZOLES AS C17,20 LYASE INHIBITORS BAYER PHARMACEUTICALS CORPORATION (US) 2003-04-03 WO disclosed
WO-2003004467-A2 THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE AGOURON PHARMACEUTICALS, INC. (US) 2003-01-16 WO disclosed