Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601051 | 0.85 | L3MBTL1 (0.45) | ALKPOLB | |
| SCHEMBL1600949 | 0.85 | L3MBTL1 (0.45) | ALK | |
| SCHEMBL1601579 | 0.82 | ALK (0.51) | ALKBRD4GSK3AGSK3B | |
| SCHEMBL1602137 | 0.81 | ALK (0.52) | ALKBRD4GSK3AGSK3BMEN1 | |
| SCHEMBL1601524 | 0.80 | ALK (0.51) | ALKBRD4GSK3AGSK3B | |
| SCHEMBL1602309 | 0.78 | ALK (0.48) | ALKBRD4GSK3AGSK3BPOLB | |
| SCHEMBL1601450 | 0.78 | ALK (0.48) | ALKACHEBRD4GSK3AGSK3B | |
| SCHEMBL1601725 | 0.76 | ALK (0.52) | ALKBRD4HTTPOLB | |
| SCHEMBL3602326 | 0.76 | GSK3A (0.48) | ALKBRD4GSK3AGSK3BKMT2A | |
| SCHEMBL1601088 | 0.75 | CAMK2D (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | disclosed |