Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | NPPA | P01160 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012073 | 0.86 | MMP2 (0.55) | ITGB3ITGA2BMMP2MMP9FOLH1 | |
| SCHEMBL7331090 | 0.86 | MMP2 (0.55) | ITGB3ITGA2BMMP2MMP9FOLH1 | |
| SCHEMBL7299119 | 0.83 | FOLH1 (0.37) | ITGB3ITGA2BMMP2MMP9FOLH1 | |
| SCHEMBL9346130 | 0.81 | ITGB3 (0.40) | ITGB3ITGA2BMMP2MMP9FOLH1 | |
| SCHEMBL27750390 | 0.80 | MMP2 (0.50) | ITGB3ITGA2BMMP2MMP9FOLH1 | |
| SCHEMBL21389077 | 0.79 | CA1 (0.35) | ITGB3ITGA2BCA1CA12CA9 | |
| SCHEMBL21389092 | 0.79 | CA1 (0.35) | ITGB3ITGA2BCA1CA12CA9 | |
| SCHEMBL1262904 | 0.77 | FOLH1 (0.43) | MMP2MMP9FOLH1HPGDSGSR | |
| SCHEMBL13416824 | 0.77 | FOLH1 (0.43) | MMP2MMP9FOLH1HPGDSGSR | |
| SCHEMBL7247656 | 0.75 | CA12 (0.42) | CA1CA12CA9RNPEPCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056817-A1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM | Bayer HealthCare AG (DE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008025509-A1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | claimed |