Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propanol SCHEMBL27517512 | 0.93 | MEN1 (0.74) | MEN1KMT2AOPRD1OPRM1OPRK1 | |
| Propane SCHEMBL27542064 | 0.91 | MEN1 (0.82) | MEN1KMT2AOPRD1OPRM1OPRK1 | |
| Norchlorcyclizine SCHEMBL7989800 | 0.90 | CYP2D6 (0.69) | MEN1KMT2AOPRD1OPRM1CYP2C19 | |
| Butyl Alcohol SCHEMBL27541713 | 0.89 | KMT2A (0.68) | MEN1KMT2AOPRD1OPRM1OPRK1 | |
| SCHEMBL219432 | 0.89 | MEN1 (1.00) | MEN1KMT2AOPRD1OPRM1USP2 | |
| SCHEMBL2794662 | 0.89 | MEN1 (1.00) | MEN1KMT2AOPRD1OPRM1USP2 | |
| SCHEMBL27485345 | 0.87 | MEN1 (0.96) | MEN1KMT2AOPRD1OPRM1USP2 | |
| Fluoride SCHEMBL27959930 | 0.87 | MEN1 (0.96) | MEN1KMT2AOPRD1OPRM1USP2 | |
| Hydrochloric Acid SCHEMBL11456225 | 0.87 | MEN1 (0.96) | MEN1KMT2AOPRD1OPRM1USP2 | |
| Hydrochloric Acid SCHEMBL7006476 | 0.87 | MEN1 (0.96) | MEN1KMT2AOPRD1OPRM1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2275854-A | — | — | None | — | — | JP | disclosed |
| WO-2009056934-A1 | 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| JP-H02275854-A | OPTICALLY ACTIVE DIHYDROPYRIDINE DERIVATIVE, PRODUCTION AND ITS USE | TAKEDA CHEM IND LTD | 1990-11-09 | — | — | JP | disclosed |