Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Norchlorcyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | BCL2 | P10415 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norchlorcyclizine SCHEMBL7993069 | 0.93 | CYP2D6 (0.71) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL7989702 | 0.92 | CYP2D6 (0.73) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL4649874 | 0.91 | CYP2D6 (0.83) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL588155 | 0.91 | CYP2D6 (0.83) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Alcohol SCHEMBL3977328 | 0.90 | MEN1 (0.79) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL6556514 | 0.90 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL588655 | 0.90 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL467086 | 0.90 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| Norchlorcyclizine SCHEMBL7139140 | 0.87 | CYP2D6 (0.81) | CYP2D6CYP19A1MEN1KMT2ATSHR | |
| SCHEMBL5363117 | 0.84 | CYP2D6 (0.76) | CYP2D6CYP19A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079188-A1 | ANTIHISTAMINIC COMPOUNDS | CIPLA LIMITED (IN) | 2001-10-25 | — | — | WO | disclosed |