Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981643 | 0.89 | IGF1R (0.50) | CLK4IGF1RFGFR1KDRCDK2 | |
| SCHEMBL3979516 | 0.86 | IGF1R (0.57) | IGF1RFGFR1KDRCDK2AURKA | |
| SCHEMBL3979717 | 0.83 | IGF1R (0.47) | CLK4IGF1RFGFR1KDR | |
| SCHEMBL4026982 | 0.82 | IGF1R (0.55) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL3926678 | 0.80 | IGF1R (0.50) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL4010199 | 0.80 | IGF1R (0.49) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL5110454 | 0.79 | IGF1R (0.64) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL5096885 | 0.78 | IGF1R (0.62) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL4018302 | 0.77 | IGF1R (0.59) | CDC7MAP4K4PIM1GSK3BCLK4 | |
| SCHEMBL4010070 | 0.77 | IGF1R (0.49) | CDC7MAP4K4PIM1GSK3BCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |