Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.55 |
| ▸ | KDR | P35968 | 11/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033236 | 0.90 | IGF1R (0.57) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3950749 | 0.88 | IGF1R (0.67) | IGF1RFGFR1KDRCLK4INSR | |
| SCHEMBL5096885 | 0.87 | IGF1R (0.62) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL4010199 | 0.85 | IGF1R (0.49) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL4010070 | 0.84 | IGF1R (0.49) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL4031157 | 0.83 | IGF1R (0.78) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4018302 | 0.83 | IGF1R (0.59) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL3926678 | 0.82 | IGF1R (0.50) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL4026978 | 0.82 | FGFR1 (0.36) | IGF1RFGFR1KDRCDC7MAP4K4 | |
| SCHEMBL3978684 | 0.82 | CDC7 (0.48) | IGF1RFGFR1KDRCDC7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |