Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981643 | 0.94 | IGF1R (0.50) | IGF1RFGFR1KDRINSRNR3C2 | |
| SCHEMBL3979717 | 0.91 | IGF1R (0.47) | IGF1RFGFR1KDRINSRROCK1 | |
| SCHEMBL3978684 | 0.86 | CDC7 (0.48) | IGF1RFGFR1KDRCDK2AURKA | |
| SCHEMBL3982541 | 0.85 | IGF1R (0.77) | IGF1RFGFR1KDRINSRFGFR2 | |
| SCHEMBL3932077 | 0.83 | IGF1R (0.59) | IGF1RFGFR1KDRINSRNR3C2 | |
| SCHEMBL4301707 | 0.82 | IGF1R (0.58) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4031157 | 0.81 | IGF1R (0.78) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3931633 | 0.80 | IGF1R (0.61) | IGF1RFGFR1KDRINSRNR3C2 | |
| SCHEMBL3983403 | 0.80 | IGF1R (0.67) | IGF1RFGFR1KDRINSRNR3C2 | |
| SCHEMBL3950749 | 0.77 | IGF1R (0.67) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |