Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974232 | 0.84 | POLB (0.62) | CA12CA9POLB | |
| SCHEMBL3978572 | 0.83 | PCSK9 (0.40) | POLBRORCPCSK9NTRK1IDO1 | |
| SCHEMBL18067567 | 0.78 | POLB (0.68) | POLBRORCPCSK9IDO1TDO2 | |
| SCHEMBL10633329 | 0.75 | CES2 (0.47) | POLBKDM4C | |
| SCHEMBL3973248 | 0.74 | KDM4E (0.42) | CA12CA9POLBRORCPCSK9 | |
| SCHEMBL30568943 | 0.73 | IDO1 (0.49) | POLBRORCPCSK9IDO1TDO2 | |
| SCHEMBL2439483 | 0.73 | IDO1 (0.49) | POLBRORCPCSK9IDO1TDO2 | |
| SCHEMBL30568894 | 0.72 | NR4A2 (0.53) | POLBIDO1TDO2CNR2 | |
| SCHEMBL7506054 | 0.72 | IDO1 (0.46) | POLBPCSK9IDO1TDO2CNR2 | |
| SCHEMBL30568918 | 0.72 | IDO1 (0.54) | POLBPCSK9IDO1TDO2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |